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Your Monday Briefing

NYTimes.com Monday, 27 April 2020
Coronavirus, Lockdown, Kim Jong-un: Here’s what you need to know.
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News video: White House Cancels Trump's Monday Coronavirus Briefing

White House Cancels Trump's Monday Coronavirus Briefing 00:46

The White House has canceled the scheduled Monday briefing.

💡 One News Page Knowledge: Other News Mentions

Coronavirus Coronavirus Subfamily of viruses in the family Coronaviridae

Frontier CEO says CDC should update coronavirus travel advice: 'Flying is not dangerous'

The CDC says travel increases the chance of getting and spreading COVID-19. It also says most viruses don't spread easily on flights.

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AP Top Stories August 7 A

Here's the latest for Friday August 7th: Coronavirus relief deal talks described as close to collapsing; Mexico records 50,000 coronavirus deaths; Unlawful..
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CBS Evening News, August 6, 2020

Coronavirus model projects U.S. death toll could hit 300,000 by December;
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'We're very far apart': Coronavirus relief negotiations left in uncertainty after Congress leaves for the weekend

Both sides push for a compromise by the end of the week, but progress on a deal has bogged down.

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Alcoholism treatment is potentially effective against COVID-19 [Video]

Alcoholism treatment is potentially effective against COVID-19

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.

Credit: ANI    Duration: 01:10Published

Lockdown Lockdown Emergency protocol that prevents people or information from leaving an area

Lockdown 'could have damaged the eyesight of thousands of children' [Video]

Lockdown 'could have damaged the eyesight of thousands of children'

The worldwide coronavirus lockdown could have potentially damaged the eyesight of thousands of children, a new study has suggested.

Credit: Cover Video STUDIO    Duration: 01:14Published
Australia: Lockdown reinstated amid second COVID-19 wave [Video]

Australia: Lockdown reinstated amid second COVID-19 wave

The Australian state of Victoria has ordered large parts of its economy to close after introduction of a nightly curfew.

Credit: Al Jazeera STUDIO    Duration: 05:46Published
COVID-19: Strict checking in Bhubaneswar amid lockdown [Video]

COVID-19: Strict checking in Bhubaneswar amid lockdown

Bhubaneswar is currently under COVID-19 lockdown. Police officials were seen checking vehicular traffic movement at the check-posts. Lockdown was imposed after tally of active cases jumped in Bhubaneswar and to curb spread of coronavirus.

Credit: ANI    Duration: 01:13Published
10-day lockdown announced in Bhopal from July 24 [Video]

10-day lockdown announced in Bhopal from July 24

While addressing the media in Bhopal on July 22, the Home Minister of Madhya Pradesh, Narottam Mishra spoke on imposing complete lockdown in Bhopal. He said, "Lockdown to be imposed in Bhopal for 10 days from 08:00 pm on July 24. It will be a complete lockdown in the city as the number of cases is rising." There are over 7,080 active cases of COVID-19 in Madhya Pradesh.

Credit: ANI    Duration: 02:18Published

Kim Jong-un Kim Jong-un Current supreme leader of North Korea

UN warns of N. Korea's miniature nuclear devices [Video]

UN warns of N. Korea's miniature nuclear devices

According to a confidential UN report, North Korea is pressing on with its nuclear weapons program and several countries believe it has "probably developed miniaturized nuclear devices to fit into the warheads of its ballistic missiles." Gloria Tso reports.

Credit: Reuters - Politics    Duration: 02:01Published
North Korean Reports First Possible Covid-19 Case [Video]

North Korean Reports First Possible Covid-19 Case

The first publicly reported suspected case of Covid-19 within North Korea's borders has been reported. North Korean leader Kim Jong Un called an emergency meeting Saturday after the infection was reported. According to CNN, Kim believes a defector who fled the country 3 years ago returned to the country while infected with coronavirus. Authorities in South Korea confirmed that a defector did in fact cross the border into North Korea.

Credit: Wochit News    Duration: 00:37Published
North Korea declares emergency over first reported COVID-19 case [Video]

North Korea declares emergency over first reported COVID-19 case

Leader Kim Jong Un holds an emergency meeting as the country's first suspected coronavirus infection is reported.

Credit: Al Jazeera STUDIO    Duration: 02:23Published
North Korea places border city in lockdown over fears of first Covid-19 patient [Video]

North Korea places border city in lockdown over fears of first Covid-19 patient

North Korean leader Kim Jong Un has placed a city near the border with SouthKorea under lockdown over concerns the country has its first coronavirus case,state media reported. The measure was taken on Friday afternoon after aresident of Kaesong was found with suspected Covid-19 symptoms, according toNorth Korea’s Central News Agency (KCNA). It added that the person is arunaway who had fled to South Korea years ago before illegally crossing theborder into the North early last week. If that person is officially declared avirus patient, he or she would be the North’s first confirmed coronavirus casewith the country steadfastly saying it has no single virus case on itsterritory, a claim questioned by outside experts.

Credit: PA - Press Association STUDIO    Duration: 00:42Published
N. Korea's Kim fires officials for extortion [Video]

N. Korea's Kim fires officials for extortion

North Korea’s leader has sacked officials building a hospital after they pressed the public for contributions, media reported on Monday, the second rebuke linked to the high-profile project in a country where such problems are rarely publicized. Lauren Anthony reports

Credit: Reuters - Politics    Duration: 01:05Published

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