A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Bhubaneswar is currently under COVID-19 lockdown. Police officials were seen checking vehicular traffic movement at the check-posts. Lockdown was imposed after tally of active cases jumped in Bhubaneswar and to curb spread of coronavirus.
While addressing the media in Bhopal on July 22, the Home Minister of Madhya Pradesh, Narottam Mishra spoke on imposing complete lockdown in Bhopal. He said, "Lockdown to be imposed in Bhopal for 10 days from 08:00 pm on July 24. It will be a complete lockdown in the city as the number of cases is rising." There are over 7,080 active cases of COVID-19 in Madhya Pradesh.
According to a confidential UN report, North Korea is pressing on with its nuclear weapons program and several countries believe it has "probably developed miniaturized nuclear devices to fit into the warheads of its ballistic missiles." Gloria Tso reports.
The first publicly reported suspected case of Covid-19 within North Korea's borders has been reported. North Korean leader Kim Jong Un called an emergency meeting Saturday after the infection was reported. According to CNN, Kim believes a defector who fled the country 3 years ago returned to the country while infected with coronavirus. Authorities in South Korea confirmed that a defector did in fact cross the border into North Korea.
North Korean leader Kim Jong Un has placed a city near the border with SouthKorea under lockdown over concerns the country has its first coronavirus case,state media reported. The measure was taken on Friday afternoon after aresident of Kaesong was found with suspected Covid-19 symptoms, according toNorth Korea’s Central News Agency (KCNA). It added that the person is arunaway who had fled to South Korea years ago before illegally crossing theborder into the North early last week. If that person is officially declared avirus patient, he or she would be the North’s first confirmed coronavirus casewith the country steadfastly saying it has no single virus case on itsterritory, a claim questioned by outside experts.
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North Korea’s leader has sacked officials building a hospital after they pressed the public for contributions, media reported on Monday, the second rebuke linked to the high-profile project in a country where such problems are rarely publicized. Lauren Anthony reports
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