India tested 7,19,364 samples for COVID-19 on August 08. 2,41,06,535 samples have been tested for SARS-CoV-2 so far, according to Indian Council of Medical Research. Country also reported highest single-day spike of 64,399 cases on August 9. Maharashtra and Andhra Pradesh continue to lead caseload, as states witnessed surge of 12,248 and 10,820 cases respectively.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Dogs trained for jsut a week can sniff out the Sars-Cov-2 virus, according to new research. They can differentiate between samples from Sars-Cov-2 infectaded patiens and non-infected people. Dogs could be used in public areas like airports, sport events, borders or other mass gatherings. The research team was led by the University of Veterinary Medicine Hannove (TIHO) in cooperation with the German Army, Hannover Medical School & the University Medical-Center Hamburg-Eppendorf.
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Metabolic syndrome increases the risk of severe disease from a viral infection, according to a review of the literature performed by a team of researchers from St. Jude Graduate School of Biomedical Sciences and the University of Tennessee Health Science Center, both in Memphis. Metabolic syndrome is a cluster of at least 3 co-occurring conditions that raise the risk of heart disease, stroke and type 2 diabetes mellitus (T2DM). These conditions include excess abdominal fat, high blood pressure, excess blood sugar, abnormalities of lipids (including excess triglycerides and cholesterol), insulin resistance and a proinflammatory state. Multiple studies have shown that obesity is associated with increased severity of influenza A, higher viral titers in exhaled breath and prolonged transmission of the virus, according to the report. Changes in the viral population may abet the emergence of more pathogenic influenza variants, according to the report. Despite the fact that influenza vaccines generate robust antibody titers in obese subjects, obesity doubles the likelihood of developing influenza. As with influenza virus, the Centers for Disease Control and Prevention recently recognized obesity as a risk factor for severe illness caused by SARS-CoV-2.
Jharkhand government is concerned over the movement of people from Bihar in Jharkhand despite the lockdown. Chief Minister Hemant Soren said on July 16, "The movement of people still not stopped, Bihar government need to think on this matter." It is noted that, the Bihar government has enforced lockdown in the state from July 16 to July 31 in view of rising Covid-19 cases. Meanwhile, to tackle the spread of SARS-CoV-2, Jharkhand government is setting up a control room in the state, "There is very little role of doctors in this infection, this need nursing and hygienic environment," Soren added.
The Canary Islands became Spain's second region to all but ban smoking in the streets on Thursday as part of measures to stop a resurgence of coronavirus infections, and other regions considered a similar ban. Gavino Garay has more.
Shortly after the World Health Organization came out with the advice not to go to the dentist until COVID-19 is under control, the American Dental Association fired back, saying it respectfully disagrees with the recommendation.
Preparations are underway in Lucknow ahead of Independence Day, Vidhan Sabha has been decked up with tri-colour lights on August 13. Similar enthusiasm was not visible in the markets of the city. Shopkeepers and wholesalers of tri-colour flags and other decorative items of Independence Day were affected due to COVID-19 pandemic. Speaking to ANI, a local wholesaler said, "Sales are down this time in the absence of buyers as COVID-19 has restricted gatherings and public celebrations." Country will celebrate Independence Day on August 15.
'Girls' star and creator Lena Dunham has shared her story on Instagram of contracting and surviving the novel coronavirus COVID-19. CNN reports Dunham said she was able to avoid going to a hospital because a doctor instructed her on how to care for herself. Johns Hopkins University data says more than 4.5 million people have been infected with the virus in the United States and 153,314 people have died.
India is now third on the Johns Hopkins University tally of countries struggling with the novel coronavirus COVID-19, following the US and Brazil. Far from flattening the curve, CNN reports India's number of cases are reaching for the stars. First observed in 1857 by Florence Nightingale, India has struggled to provide basic public health services for its people. On the Health Care Access and Quality Index, India trails its neighbors Myanmar, Sri Lanka, Bhutan, and Bangladesh.
Fox News host Chris Wallace held a wide-ranging ― and at times, testy ― interview with US President Donald Trump on Sunday. HuffPost reports the president repeated his unsubstantiated claim that the novel coronavirus COVID-19 will simply 'disappear' one day. Johns Hopkins University data indicates the US leads the world in known coronavirus infections and deaths. Over 3.7 million cases of COVID-19 and 140,000 deaths due to the virus have been recorded nationwide.
Countries including the US, South Africa and India are struggling to hold down rising rates of coronavirus as global deaths from Covid-19 surged past 600,000.Concerns are rising that the pandemic has found fresh legs over the past few weeks, with Johns Hopkins University and the World Health Organisation (WHO) both recording daily highs in newly reported infections.The Department for Health and Social Care said on Friday it was “pausing” publication of daily death figures for the whole of the UK after Health Secretary Matt Hancock ordered a review into claims by researchers that there were “statistical flaws” in the way they are calculated.
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Countries including the US, South Africa and India are struggling to hold down rising rates of coronavirus as global deaths from Covid-19 surged past 600,000.Concerns are rising that the pandemic has found fresh legs over the past few weeks, with Johns Hopkins University and the World Health Organisation (WHO) both recording daily highs in newly reported infections.
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U.S. Health Secretary Alex Azar attacked China's response to the coronavirus pandemic on Tuesday (August 11) and said that if such an outbreak had emerged in Taiwan or the United States it could have been "snuffed out easily."
Researchers from Yangzhou University have shown that an uncovered toilet can eject infected aerosol droplets up to three feet, or one meter, in the air, according to a study published on June 16 in the journal Physics of Fluids.
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President Donald Trump said "99%" of coronavirus cases in the US are "totally harmless." Dr. Anthony Fauci is the nation's top infectious-disease expert. Fauci said Trump's claim is "false." "I'm trying to figure out where the president got that number," Fauci said in a Financial Times interview published Friday. Business Insider reports that there is overwhelming evidence of COVID-19's effects contradicts Trump's statement.
The UK left the European Union on January 31. Here we look at the latest figures and key dates in the ongoing Brexit process. Quote from Sarah Hewin, Chief economist at Standard Chartered, speaking to the Financial Times.
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Peter Kneffel/picture alliance via Getty Images The Philippines is investigating local businesses that partnered the collapsed German payments company Wirecard, the Financial Times reported. Wirecard went into administration and its former CEO Markus Braun was arrested after the firm claimed that more than $2 billion had disappeared from its balance sheet. Its auditor EY said the firm committed elaborate fraud.
So far, there is no evidence that COVID-19 can be transmitted by the water from water fountains. But according to HuffPost, experts say the virus may linger on surfaces. Therefore, it's best to avoid fountains if you can, or to limit any direct contact when using them. Filling a water bottle from a fountain, instead of drinking from it, means you won't leave saliva on the fountain. That makes it safer for you and for others.
Rajasthan Governor Kalraj Mishra on August 13 called Plasma therapy an effective mode of treatment for COVID-19. He said, "Plasma therapy is an effective mode of treatment for COVID-19. I urge all the people in the state, who have defeated Corona, to come forward and donate their blood plasma so that COVID patients can get a new life through plasma therapy."
From the supply of antiviral drug remdesivir stabilising in India after shortage as per producer Cipla, to Russia becoming the first nation to declare a vaccine ready for use - here are the top news updates on the Covid-19 pandemic. The health of India's former President Pranab Mukherjee has worsened and his condition is critical, as per doctors. He had recently tested positive for Sars-CoV-2 coronavirus infection and also undergone an emergency surgery for a brain clot on August 10. Meanwhile, noted Urdu poet Rahat Indori passed away. He was suffering from Covid and experienced two heart attacks before succumbing. The Railways ministry has announced that regular passenger train services across the country will continue to remain suspended until further orders. However, 230 special trains will continue to ply between select destinations. India's Covid tally has crossed the 22.68 lakh-mark with the country noting 50,000+ new cases every day. India's death toll is past 45,200 while over 15.83 lakh patients have been discharged, suggesting a healthy recovery rate. In international news, schools have begun to reopen in countries like the United States of America and the United Kingdom. This, even as a report suggested that around 97,000 children in US contracted Covid in the last 2 weeks of July. New Zealand broke its streak of 102 days without a locally transmitted case by finding a new infection. Prime Minister Jacinda Ardern put Auckland under lockdown. The country now has 22 active cases, with the total Covid tally at a little over 1,200. Watch the full video for more.
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From two more Union ministers testing positive, to hospital staff preventing a suicide bid by a patient - here are the top news updates on the Covid-19 pandemic. After Union Home minister Amit Shah and petroleum minister Dharmendra Pradhan, MoS Heavy Industries Arjun Ram Meghwal, and MoS Agriculture Kailash Choudhary have tested positive for Covid infection. In Kolkata, hospital staff were able to stop a patient from jumping out after breaking a window pane with an oxygen cylinder. The Central government has asked state administrations to step up testing of grocery shop staff, and vegetable and fruit vendors, as they can potentially spread the virus to a large number of people. The southern state of Tamil Nadu has decided to reopen places of worship with some limitations from August 10. Meanwhile, Andhra Pradesh saw a massive jump in new cases with over 10,000 infections being reported on Saturday. India's total case tally has crossed the 20.88 lakh mark with over 42,500 deaths so far. While India has 6.19 lakh active cases, over 14.27 lakh patients have been discharged so far. In international news, some states in the United States of America have allowed schools to reopen even as the US remains the worst Covid-hit nation so far. The US has had over 48 lakh cases, while the second worst-hit country, Brazil is at 29 lakh cases. Watch the full video for more updates on the spread of the Sars-CoV-2 coronavirus.
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Prime Minister Narendra Modi inaugurated the Rashtriya Swachhata Kendra in Delhi on Saturday. He said that like the Quit India Movement, which was launched under the leadership of MK Gandhi on August 8, 1942, the Swachhata Kendra's inauguration symbolises the ongoing cleanliness drive, or 'Filth, Quit India' movement. Referring to the Covid-19 pandemic, the Prime Minister said that many habits of hygiene propagated under the Swachh Bharat Abhiyan were helping the country in its fight against the Sars-CoV-2 coronavirus. The PM also took a dig at the Opposition, asking his audience to imagine what the situation would've been if Covid-19 had struck before 2014, when open defecation was prevalent. India has reported over 20 lakh Covid cases so far, making it the third worst-hit country in the world. However, with over 42,500 deaths so far, India has among the lowest Covid mortality rates, coupled with a high recovery rate. Watch the full video for more.
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From another minister in the Narendra Modi cabinet testing positive for infection, to the progress report of India's indigenously-developed vaccine candidates - here are the top news updates on the Covid-19 pandemic. Union minister of petroleum and natural gas, and steel, Dharmendra Pradhan, tested positive days after Union Home minister Amit Shah confirmed his positive diagnosis. Meanwhile, other members of the Union cabinet, like Ravi Shankar Prasad and Babul Supriyo, are quarantining themselves as a precaution. On the medical front, India's two vaccine candidates have completed phase 1 of human clinical trials. The vaccines have been developed by Bharat Biotech, ICMR and Zydus Cadila. The Jammu and Kashmir administration has decided to allow all places of worship to reopen from August 16. Earlier, the authorities had decided to cancel the annual Amarnath Yatra due to the Covid pandemic. In economic news, the International Monetary Fund has said that Covid might exacerbate the narrowing of global current account imbalances which was happening due to trade slowdown in 2019. Watch the full video for the other updates on the spread of the Sars-CoV-2 coronavirus.
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From another Ayodhya priest testing positive days ahead of Prime Minister Narendra Modi's visit, to the government issuing guidelines for gymnasiums and yoga centres ahead of their reopening from August 5 - here are the top news updates on the Covid-19 pandemic. The World Health Organisation has reportedly completed the groundwork in China for an investigation into the origin of the virus which causes the Covid-19 illness. WHO Director General, Tedros Adhanom Ghebreyesus, also warned the world that although there is hope of development of an effective vaccine, there is also the possibility that we might never have a 'silver bullet' against the disease. Meanwhile, South Korean envoy to India, Shin Bong-kil, said that India has always been important when it comes to vaccines and the country also has a strong pharmaceutical industry. A controversy has broken out over the admission of Union Home minister Amit Shah to a private hospital in Gurugram after he tested positive for Covid infection. Congress' Shashi Tharoor said that patronage of the powerful is important to maintain public faith in government institutions. India also crossed a milestone in its fight against the virus. The country passed the landmark of 2 crore total tests on August 2. Watch the full video for the other updates regarding the spread of the Sars-CoV-2 coronavirus.
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