[NFA] U.S. President Donald Trump took a public swipe at White House coronavirus task force coordinator Dr. Deborah Birx a day after she said infections from the virus were "extraordinarily widespread" in the U.S. Lisa Bernhard produced this report.
[NFA] China's ByteDance has agreed to divest the U.S. operations of TikTok completely in a bid to save a deal with the White House, after President Donald Trump said he had decided to ban the app, two people familiar with the matter told Reuters. This report was produced by Jonah Green.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
On the Fourth of July, Kanye West announced he's running for president in 2020. Business Insider says West has enjoyed a friendship with President Trump. They complimented each other in the press until Trump ran for President. West didn't vote in 2016 - but says if he voted it would have been for Trump. In April 2018, West sent out a series of tweets expressing admiration for Trump. West called Trump his "brother" and they both have "dragon energy.
ADP is reporting 167,000 jobs were added in the private sector in July. The number is a significant miss compared to expected job growth last month. The report comes ahead of the monthly jobs report,..