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July 4th muted as COVID-19 cases soar

Video Credit: Reuters Studio - Duration: 01:50s - Published
July 4th muted as COVID-19 cases soar

July 4th muted as COVID-19 cases soar

[NFA] Coronavirus cases are rising in 37 U.S. states, many of which are canceling traditional Independence Day celebrations to stop the spread.

This report produced by Jillian Kitchener.

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Coronavirus Coronavirus Subfamily of viruses in the family Coronaviridae

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Alcoholism treatment is potentially effective against COVID-19

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.

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Independence Day (United States) Independence Day (United States) Federal holiday in the United States

A Timeline Of President Trump's Friendship With Kanye [Video]

A Timeline Of President Trump's Friendship With Kanye

On the Fourth of July, Kanye West announced he's running for president in 2020. Business Insider says West has enjoyed a friendship with President Trump. They complimented each other in the press until Trump ran for President. West didn't vote in 2016 - but says if he voted it would have been for Trump. In April 2018, West sent out a series of tweets expressing admiration for Trump. West called Trump his "brother" and they both have "dragon energy.

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Kanye West Says He's Running for President, Yeezy Receives $2M-Plus From Federal Pandemic Loan | THR News [Video]

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Kanye West announced on the Fourth of July that he plans to run for president in 2020.

Credit: The Hollywood Reporter    Duration: 01:20Published
Hilary Duff slams Independence Day revellers for not wearing masks [Video]

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Hilary Duff has expressed exasperation at people not following social distancing practices or wearing masks in public.

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Neil Young objects to Donald Trump using his songs [Video]

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Neil Young has stated he is 'not OK' with Donald Trump using his songs at his Fourth of July weekend event.

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Trump vows to 'defend' America's history in July 4th celebrations [Video]

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The US celebrated Independence Day as coronavirus cases pass 2.8 million.View on euronews

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