Study links increase in delirium, rare brain inflammation and stroke to COVID-19
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Study links increase in delirium, rare brain inflammation and stroke to COVID-19
Neurological complications of COVID-19 can include delirium (abrupt change in the brain that causes mental confusion and emotional disruption), brain inflammation, stroke, and nerve damage, a new study has revealed.
It identified one rare and sometimes fatal inflammatory condition, known as ADEM, which appears to be increasing in prevalence due to the pandemic.
Some patients in the study did not experience severe respiratory symptoms, and the neurological disorder was the first and main presentation of COVID-19.
The virus causing COVID-19, SARS-CoV-2, was not detected in the cerebrospinal brain fluid of any of the patients tested, suggesting the virus did not directly attack the brain to cause the neurological illness.
Further research is needed to identify why patients were developing these complications.
In some patients, the researchers found evidence that the brain inflammation was likely caused by an immune response to the disease, suggesting that some neurological complications of COVID-19 might come from the immune response rather than the virus itself.
Delhi Chief Minister Arvind Kejriwal urge people to donate oximeters in villages to support rural areas amid coronavirus pandemic. Kejriwal, in his press briefing on Independence Day, shared a few tips on Covid-19 containment and treatment. The Delhi CM said home-isolation has helped Delhi in tackling Coronavirus. Kejriwal urged people to come out and take responsibility as Covid-19 spreads in rural India. Kejriwal appealed to AAP workers to support villages and provide oximeters to those who need it. Oximeters help in measuring the oxygen level and are found to be extremely useful for coronavirus patients who in many cases battle breathlessness due to lack of oxygen. "My appeal to people is to donate to AAP as many oximeters as possible so that every AAP worker can take the responsibility of his village to measure the oxygen level of people who have fever or breathlessness. We can save the lives of people through oximeters," he said. The chief minister also advised states to implement Delhi's home isolation model that can help in their battle against coronavirus.
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SI Sunita Maan on being invited to the Rashtrapati Bhavan as coronavirus warrior awardee expressed happiness over her selection. She created awareness about COVID-19. "In lockdown, none knew about the virus. We distributed essentials and sensitizers. I feel lucky to be chosen from 1 lakh Delhi Police personnel. Can't describe the exact feeling," SI Sunita Maan said.
Prime Minister Narendra Modi on Independence Day said that corona warriors have lived the mantra of 'Seva Parmo Dharma' and served the people of India. "We're going through distinct times. I can't see young children in front of me today (at Red Fort). Corona has stopped everyone. In these times of COVID, corona warriors have lived the mantra of 'Seva Parmo Dharma' and served the people of India. I express my gratitude to them," said Modi.
India tested 7,19,364 samples for COVID-19 on August 08. 2,41,06,535 samples have been tested for SARS-CoV-2 so far, according to Indian Council of Medical Research. Country also reported highest single-day spike of 64,399 cases on August 9. Maharashtra and Andhra Pradesh continue to lead caseload, as states witnessed surge of 12,248 and 10,820 cases respectively.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Dogs trained for jsut a week can sniff out the Sars-Cov-2 virus, according to new research. They can differentiate between samples from Sars-Cov-2 infectaded patiens and non-infected people. Dogs could be used in public areas like airports, sport events, borders or other mass gatherings. The research team was led by the University of Veterinary Medicine Hannove (TIHO) in cooperation with the German Army, Hannover Medical School & the University Medical-Center Hamburg-Eppendorf.
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Metabolic syndrome increases the risk of severe disease from a viral infection, according to a review of the literature performed by a team of researchers from St. Jude Graduate School of Biomedical Sciences and the University of Tennessee Health Science Center, both in Memphis. Metabolic syndrome is a cluster of at least 3 co-occurring conditions that raise the risk of heart disease, stroke and type 2 diabetes mellitus (T2DM). These conditions include excess abdominal fat, high blood pressure, excess blood sugar, abnormalities of lipids (including excess triglycerides and cholesterol), insulin resistance and a proinflammatory state. Multiple studies have shown that obesity is associated with increased severity of influenza A, higher viral titers in exhaled breath and prolonged transmission of the virus, according to the report. Changes in the viral population may abet the emergence of more pathogenic influenza variants, according to the report. Despite the fact that influenza vaccines generate robust antibody titers in obese subjects, obesity doubles the likelihood of developing influenza. As with influenza virus, the Centers for Disease Control and Prevention recently recognized obesity as a risk factor for severe illness caused by SARS-CoV-2.
Jharkhand government is concerned over the movement of people from Bihar in Jharkhand despite the lockdown. Chief Minister Hemant Soren said on July 16, "The movement of people still not stopped, Bihar government need to think on this matter." It is noted that, the Bihar government has enforced lockdown in the state from July 16 to July 31 in view of rising Covid-19 cases. Meanwhile, to tackle the spread of SARS-CoV-2, Jharkhand government is setting up a control room in the state, "There is very little role of doctors in this infection, this need nursing and hygienic environment," Soren added.