White House health experts are warning of a slow rise in the percentage of people testing positive for coronavirus in U.S. cities such as Boston, Chicago, Detroit and Washington and urged local leaders to remain vigilant to avoid a surge. Lisa Bernhard produced this report.
World stocks ended four days of gains on Friday after U.S. President Donald Trump cranked up simmering tensions with China by banning U.S. transactions with two popular Chinese apps, Tencent's WeChat and ByteDance's TikTok. Ciara Lee reports
From Covid patients dying in Ahmedabad to AAP government sending a proposal to L-G, here are the top updates on coronavirus pandemic. In Gujarat’s Ahmedabad, eight Covid-19 patients were killed in a fire an ICU ward of a hospital. Ambulances and fire engines were rushed to the spot, a probe in the incident was ordered. CPI (M) leader Shyamlal Chakraborty, who was being treated after he tested positive for Covid-19, died on Thursday. The leader had served three terms as transport minister in Bengal. Chongqing Zhifei Biological Products Co. shares surged 80% after China’s drug controller approved clinical trials for Covid vaccine. Zhifei chairman Jiang Rensheng became the fastest growing fortune among the world’s 500 wealthiest people. US top health expert Anthony Fauci expects tens of millions of vaccines for Covid-19 by early 2021. Fauci said there could be a billion vaccine doses by the end of 2021. India’s Covid-19 cases tally nears 2 million cases with recovery rate improving to 67.62%. Watch the full video for more details.
Credit: HT Digital Content Duration: 03:49Published
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Credit: ANI Duration: 01:10Published
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