A scripted drama series about Hillary Clinton could be coming to Hulu. Actress Anna Camp opens up about testing positive for and battling the novel coronavirus. Plus, ‘Tenet’ is the first movie to pursue a staggered rollout, which could become the ne
Credit: The Hollywood Reporter Duration: 02:06Published
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Another former member of the Ellen Show has come out to detail toxic behind the scenes behavior. In an instagram post DJ and actor Tony Okungbowa addressed recent reports that the daytime talk show has a toxic workplace culture. DJ Tony was on the show for ten years. "I did experience and feel the toxicity of the environment." DJ Tony says he stands former colleagues who came forward and demanded a better workplace.
Rapper Badshah on Friday reached the Crime Branch office here to record his statement in the fake social media followers case, an official said. The Crime Intelligence Unit (CIU), which is investigating the case, had earlier summoned the singer. The rapper's Instagram account had cropped up during the investigation and so it was decided to call him to record his statement in the case, the official said.
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COVID-19 Forces 20 Percent of MLB Teams to Delay Games Pro baseball has been back for a little over a week, but COVID-19 is causing issues. According to Fox News, three games were postponed on Friday..
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With coronavirus cases rising in parts of the country, President Donald Trump issued a warning Thursday. Plus, the FDA says a vaccine could be even closer than originally thought; CBS2's Jessica Layton..