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MLB Postpones 2 Games After Teams Are Hit by Coronavirus

Video Credit: Cover Video STUDIO - Duration: 00:58s - Published
MLB Postpones 2 Games After Teams Are Hit by Coronavirus

MLB Postpones 2 Games After Teams Are Hit by Coronavirus

Both the Miami Marlins opener against the Baltimore Orioles and the Philadelphia Phillies' game against the Yankees were scheduled for Monday night.

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Major League Baseball Major League Baseball Professional baseball league

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Miami Marlins Miami Marlins Baseball team and Major League Baseball franchise in Miami, Florida, United States

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Miami Marlins season on pause after coronavirus outbreak: What we know now

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Coronavirus Coronavirus Subfamily of viruses in the family Coronaviridae

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Alcoholism treatment is potentially effective against COVID-19 [Video]

Alcoholism treatment is potentially effective against COVID-19

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.

Credit: ANI    Duration: 01:10Published
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Health experts warn U.S. cities of 'trouble ahead'

White House health experts are warning of a slow rise in the percentage of people testing positive for coronavirus in U.S. cities such as Boston, Chicago, Detroit and Washington and urged local leaders to remain vigilant to avoid a surge. Lisa Bernhard produced this report.

Credit: Reuters - Politics    Duration: 02:19Published

Baltimore Orioles Baltimore Orioles Baseball team and Major League Baseball franchise in Baltimore, Maryland, United States


New York Yankees New York Yankees Baseball team and Major League Baseball franchise in the Bronx, New York, United States

Former Yankees pitcher jabs Brett Gardner for opposite-field homerun, says 'league has a baseball problem'

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Doctor Fauci's Topps Baseball Card Sets New Record [Video]

Doctor Fauci's Topps Baseball Card Sets New Record

Doctor Anthony Fauci threw MLB's first pitch of the shortened 2020 season at Sunday's game between the Washington Nationals and the New York Yankees.

Credit: Cover Video STUDIO    Duration: 01:02Published
Marlins' season halted due to COVID-19 outbreak [Video]

Marlins' season halted due to COVID-19 outbreak

Major League Baseball has postponed all Miami Marlins games through Sunday after four additional players tested positive for COVID-19, bringing the total number of cases within the club to 17 over the last five days according to reports. Freddie Joyner has more

Credit: Reuters - Politics    Duration: 01:41Published

Philadelphia Phillies Philadelphia Phillies Wikimedia list article

Phillies-Blue Jays series postponed, another big blow to MLB's week-old 2020 season

After two Phillies staff members tested positive for coronavirus, the upcoming weekend series against the Blue Jays was postponed.

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