Cincinnati is a major city in the U.S. state of Ohio, and is the government seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line with Kentucky. The city drives the Cincinnati–Middletown–Wilmington combined statistical area, which had a population of 2,172,191 in the 2010 census making it Ohio's largest metropolitan area. With a population of 301,301, Cincinnati is the third-largest city in Ohio and 65th in the United States. Its metropolitan area is the fastest growing economic power in the Midwestern United States based on increase of economic output and it is the 28th-largest metropolitan statistical area in the U.S. Cincinnati is also within a day's drive of 49.70% of the United States populace.