British Prime Minister Boris Johnson said on Monday (July 20) he could not promise there would be successful vaccine against COVID-19 developed by the end of this year, saying "we're not there yet" even as Britain lines up supplies.
With more than 20 COVID-19 vaccines in clinical trials, the collaboration between Johnson & Johnson and Beth Israel Deaconess in Boston is getting $1 billion in U.S. funding. Lead researcher Dan Barouch charts the road ahead. (Produced by Dan Fastenberg)
On Thursday, Johnson & Johnson detailed it's quarterly earnings. The company said shoppers are not buying skincare and beauty products as more and more people remain isolated at home. Business Insider said the negative hit on skincare has cost the company 3.4% in terms of worldwide sales.
The corporation behind Johnson's, Neutrogena, Clean & Clear, and more has just vowed to stop selling two lines of skin-care products used for skin-lightening overseas. On June 19, in the wake of the recent Black Lives Matter uprising, Johnson & Johnson said that it will cease production of two different lines from Asian and Middle Eastern markets that were used for skin-lightening lines.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
White House health experts are warning of a slow rise in the percentage of people testing positive for coronavirus in U.S. cities such as Boston, Chicago, Detroit and Washington and urged local leaders to remain vigilant to avoid a surge. Lisa Bernhard produced this report.
Wearing a mask, social distancing, and regular handwashing could reduce the spread of COVID-19. In fact, it could reduce the spread by as much as 65%, according to reports at UPI. Researchers from the Netherlands also applaud government-imposed social distancing measures. This includes closure of non-essential businesses and "stay-at-home" orders. These moves could delay the peak of an epidemic by up to seven months.
Charles Michel who chairs the summit is expected to reveal new proposals ahead of Sunday's meeting to bridge the gap between the 'frugal four' countries (Austria, Denmark, Netherlands and Sweden) and other countries who don't want to see big cuts and conditions added to the recovery fund.View on euronews
Credit: euronews (in English) Duration: 01:30Published
European Union leaders may not reach a deal on a coronavirus stimulus plan on Sunday (July 19), German Chancellor Angela Merkel said as marathon negotiations ran into a third day. Francis Maguire reports.
Sen. Chuck Grassley will not attend the Republican National Convention for the first time in his 40-year Senate career due to concerns about the coronavirus.... Seattle Times Also reported by •SeattlePI.com