A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
iPhone 12 expected to launch in the fall. Business Insider reports that this is the worst time to purchase a new iPhone. Insider said buyers should wait for the newest model that's expected to come with 5G support and the latest Apple processor. Some consumers don't care about having the latest iPhone. Apple typically discounts certain older models when introducing new ones. Consumers in need of a cheaper iPhone can pick up an iPhone SE for $399.
Walmart delayed the July launch of its subscription service. Business Insider reports that Walmart needs to debut soon to avoid missing out on holiday sales. The 2020 holiday shopping season is most likely going to move entirely online. Walmart+ has a clear chance to highlight its value to consumers. Walmart was originally set to introduce its Walmart+ subscription service this spring. It pushed the debut back to July due to the coronavirus pandemic, but its launch has now been postponed again.
Nintendo surged as much as 6% on Thursday, reports Business Insider. The video game company said first-quarter earnings soared 428% while sales more than doubled. Video game companies have seen a surge in business since the COVID-19 pandemic outbreak. Consumers are looking to entertain and distract themselves while sheltering in place. Driving the strength in Nintendo's business included growing demand for its Nintendo Switch.
On Thursday, the U.S. Centers for Disease Control and Prevention said up to 20% of pregnant women in the U.S. drink alcohol during their first trimester. According to Business Insider the CDC also said that more than 10% admit to binge drinking during that time. In addition, nearly 5% reported consuming alcohol at least once during the second and third trimesters, the CDC said. Nearly 40% indicated that they also used at least one other substance , commonly tobacco and marijuana.
Business Insider reports that banks' and tech giants' earnings largely impressed Wall Street. Bank of America says discount stores are set to post similarly positive results, according to Bank of America. BoA analysts expect the sector's second-quarter figures to hold strong thanks to rising food sales and improvement in general merchandise revenue. Thanks to momentum in higher-profit categories and successful online operations Walmart, Target, and Dollar Tree are in good positions.