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Coronavirus news and updates: Are asymptomatic people really spreading COVID-19?; UN won't meet in NYC

USATODAY.com Tuesday, 9 June 2020
These are the top headlines on COVID-19 from the US and around the world.
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Coronavirus Coronavirus Subfamily of viruses in the family Coronaviridae

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Alcoholism treatment is potentially effective against COVID-19 [Video]

Alcoholism treatment is potentially effective against COVID-19

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.

Credit: ANI    Duration: 01:10Published
Health experts warn U.S. cities of 'trouble ahead' [Video]

Health experts warn U.S. cities of 'trouble ahead'

White House health experts are warning of a slow rise in the percentage of people testing positive for coronavirus in U.S. cities such as Boston, Chicago, Detroit and Washington and urged local leaders to remain vigilant to avoid a surge. Lisa Bernhard produced this report.

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New York City New York City Largest city in the United States

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New York City combats coronavirus spread with quarantine checkpoints

New York City is setting quarantine checkpoints for visitors and residents to contain the spread of the coronavirus. The mandate joins the state's obligatory..
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NYC greeting travelers with quarantine reminder

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Thousands still without power in New York, New Jersey, Connecticut days after Tropical Storm Isaias

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New York sues to break up the NRA [Video]

New York sues to break up the NRA

[NFA] New York state's attorney general sued to dissolve the National Rifle Association on Thursday, alleging senior leaders of the non-profit group diverted millions of dollars for personal use. At the same time, the attorney general for Washington, D.C., filed suit against the NRA, alleging the misuse of charitable funds. This report produced by Jillian Kitchener.

Credit: Reuters Studio    Duration: 02:08Published

Coronavirus disease 2019 Coronavirus disease 2019 Infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2

Pinellas County sisters hope to raise thousands for pediatric cancer with virtual lemonade stand [Video]

Pinellas County sisters hope to raise thousands for pediatric cancer with virtual lemonade stand

A local non-profit's big event of the year is having to go virtual because of COVID-19. Story: https://wfts.tv/2DDQFLQ

Credit: ABC Action News    Duration: 00:29Published

The Denver Broncos are misting their players to protect against COVID-19. Does it actually work?

The Broncos are using a walk-through sanitizing booth that mists players with a non-toxic spray called microSURE that claims to create "tiny spikes."

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Video of Trump Saying Kids Are 'Nearly Immune' to COVID-19 Removed From Social Media [Video]

Video of Trump Saying Kids Are 'Nearly Immune' to COVID-19 Removed From Social Media

The president shared the video on his Twitter account and Facebook page.

Credit: Cover Video STUDIO    Duration: 01:18Published

COVID compounds Pennsylvania's fracking industry problems

"If the industry were a patient, we could say that it has a number of pre-existing conditions, and that's made the prognosis in the wake of COVID-19 way more..
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