Treatment-Resistant Hypertension Market is Anticipated to Showcase Immense Growth by 2032, Predicts DelveInsight | Key Companies - Idorsia, Janssen Biotech, Quantum Genomics, CinCor Pharma, Ionis Pharmaceuticals, Vifor Pharma

DelveInsight analysts project a favorable treatment-resistant hypertension market expansion, primarily driven by a rise in prevalence and the expected introduction of new therapies throughout the forecast period spanning from 2019 to 2032.

New York, USA, April 09, 2024 (GLOBE NEWSWIRE) -- *Treatment-Resistant Hypertension Market is Anticipated to Showcase Immense Growth by 2032, Predicts DelveInsight | Key Companies - Idorsia, Janssen Biotech, Quantum Genomics, CinCor Pharma, Ionis Pharmaceuticals, Vifor Pharma*

*DelveInsight analysts project a favorable treatment-resistant hypertension market expansion, primarily driven by a rise in prevalence and the expected introduction of new therapies throughout the forecast period spanning from 2019 to 2032.*

DelveInsight’s *Treatment-Resistant Hypertension Market Insights* report includes a comprehensive understanding of current treatment practices, treatment-resistant hypertension emerging drugs, market share of individual therapies, and current and forecasted treatment-resistant hypertension market size from 2019 to 2032, segmented into 7MM [the United States, the EU-4 (Italy, Spain, France, and Germany), the United Kingdom, and Japan].

*Key Takeaways from the Treatment-Resistant Hypertension Market Report*

· According to DelveInsight’s analysis, the market size for treatment-resistant hypertension reached *USD 13.4 billion* in 2021 across the 7MM and is expected to grow with a significant CAGR by 2032.
· DelveInsight’s analysis reveals that the overall prevalent cases of treatment-resistant hypertension in the US were reported as *~10 million* in 2021. 
· Prominent companies working in the domain of treatment-resistant hypertension, including *Idorsia Ltd, Janssen Biotech, Quantum Genomics SA, CinCor Pharma, Ionis Pharmaceuticals, Vifor Pharma, KBP Biosciences*, and others, are actively working on innovative drugs for treatment-resistant hypertension. These novel treatment-resistant hypertension therapies are anticipated to enter the treatment-resistant hypertension market in the forecast period and are expected to change the market.
· Some of the key therapies for treatment-resistant hypertension treatment include *Aprocitentan, Firibastat (QGC001), CIN-107, IONIS-AGT-LRx, Veltassa (Patiromer), KBP-5074**, *and others. 

Discover which therapies are expected to grab the treatment-resistant hypertension market share @ *Treatment-Resistant Hypertension Market Report*

*Treatment-Resistant Hypertension Overview*

Hypertension is a medical condition characterized by persistently elevated blood pressure within the blood vessels. According to the World Health Organization, an estimated 1.28 billion adults aged 30–79 worldwide suffer from HTN. This condition significantly amplifies the risks of various diseases, including those affecting the heart, brain, kidneys, and other organs. Resistant hypertension (RHTN) is described as uncontrolled blood pressure that persists despite the utilization of three or more antihypertensive medications from different classes. These typically include a thiazide-like diuretic, a long-acting calcium channel blocker, and a renin–angiotensin system blocker, such as an ACE (angiotensin-converting enzyme) inhibitor or an ARB (angiotensin receptor blocker), administered at maximum or maximally tolerated doses. The estimated prevalence of RHTN among treated HTN patients is approximately 10–13%. Factors associated with RHTN include older age, black race, left ventricular hypertrophy, chronic kidney disease, obesity, and diabetes, with a higher incidence in females compared to males.

*Treatment-Resistant Hypertension Epidemiology Segmentation*

The treatment-resistant hypertension epidemiology section provides insights into the historical and current treatment-resistant hypertension patient pool and forecasted trends for the 7MM. It helps recognize the causes of current and forecasted patient trends by exploring numerous studies and views of key opinion leaders.

The *treatment-resistant hypertension market report* proffers epidemiological analysis for the study period 2019–2032 in the 7MM segmented into:

· Total Prevalent Cases of Treatment-resistant Hypertension
· Age-specific Cases of Treatment-resistant Hypertension
· Gender-specific Cases of Treatment-resistant Hypertension

Download the report to understand which factors are driving treatment-resistant hypertension epidemiology trends @ *Treatment-Resistant Hypertension Epidemiological Insights*

*Treatment-Resistant Hypertension Treatment Market *

The primary approaches utilized to address treatment-resistant hypertension involve discontinuing medications that may interfere, employing diuretic treatment, utilizing mineralocorticoids, adopting combination therapies, and considering spironolactone as the fourth-line agent for TRHTN management. Additionally, non-pharmacological interventions, such as lifestyle modifications (weight loss, regular exercise, adherence to a high-fiber, low-fat, low-salt diet), and moderation of alcohol consumption, should be recommended as appropriate. It is advisable to withdraw or adjust potentially interfering medications within clinically acceptable limits. Moreover, if obstructive sleep apnea is present, appropriate treatment measures should be implemented.

Avoid or discontinue medications, especially *NSAIDs*, that might disrupt blood pressure regulation in patients with resistant hypertension. Although it can be challenging in practice, strive to use the minimum effective dosage and consider gradual reduction when feasible. Close monitoring of blood pressure is crucial when starting treatment with such agents, and be prepared to make adjustments to the antihypertensive regimen as needed.

Individuals experiencing treatment-resistant hypertension often exhibit improper volume expansion, which adds to the challenge of managing their condition. The inclusion of a diuretic becomes crucial to optimize blood pressure control in such cases. For the majority of patients, the optimal choice is a long-acting thiazide diuretic. In a study where *hydrochlorothiazide 50 mg and chlorthalidone 25 mg* were compared in a blinded manner, the latter demonstrated superior 24-hour ambulatory blood pressure reduction, particularly during overnight hours.

Learn more about the FDA-approved drugs for treatment-resistant hypertension @ *Drugs for* *Treatment-Resistant Hypertension Treatment** *

*Treatment-Resistant Hypertension Emerging Drugs and Companies*

Some of the drugs in the pipeline include *firibastat (Quantum Genomics), aprocitentan (Idorsia Pharmaceuticals), CIN-107 (CinCor Pharma), IONIS-AGT-LRx (Ionis Pharmaceuticals), patiromer (Vifor Pharma)*, among others.

*Firibastat*, originally known as *QGC001*, is a prodrug designed to deliver EC33 in the brain. EC33 acts as a specialized inhibitor of aminopeptidase A, thereby halting the production of Angiotensin III in the brain. This unique mechanism of action makes firibastat a promising option for treating hypertension. It targets a specific hormonal profile found in hypertensive patients, particularly those with low renin and high vasopressin levels, known as the Low Renin High Vasopressin (LRHV) profile.

*CIN-107*, a meticulously targeted inhibitor of aldosterone synthase, is under development to address significant medical gaps, such as resistant hypertension and primary aldosteronism. Its mechanism involves the renin-angiotensin-aldosterone system (RAAS), responsible for regulating the body's fluid and electrolyte equilibrium.

As these therapies continue to undergo rigorous clinical evaluation and gain regulatory approval, they are expected to expand the treatment options available to patients, potentially transforming the management of TRH and improving patient outcomes. Moreover, the introduction of these therapies is likely to stimulate competition and innovation within the pharmaceutical and medical device industries, leading to a dynamic and evolving market landscape characterized by increased diversity and efficacy in hypertension management strategies. 

To know more about treatment-resistant hypertension clinical trials, visit @ *Treatment-Resistant Hypertension Treatment Drugs** *

*Treatment-Resistant Hypertension Market Dynamics*

The treatment-resistant hypertension market dynamics are anticipated to change in the coming years. The anticipated launch of pioneering *drugs with novel MoA*, such as *aprocitentan and CIN-107*, is poised to stimulate the growth of the resistant hypertension market. The robust drug pipeline featuring MoAs distinct from the *Standard of Care (SoC)*, exemplified by firibastat (BAPAI molecule), holds the promise of providing alternative *therapeutic avenues for RHTN patients* who may be intolerant or contraindicated to spironolactone. Despite *spironolactone *being the preferred add-on treatment based on the *PATHWAY-2 study*, there is a pressing, unmet need for alternative treatment options offering improved side-effect profiles, innovative MoAs, ease of administration, and other essential attributes.

Furthermore, many potential therapies are being investigated for the treatment of treatment-resistant hypertension, and it is safe to predict that the treatment space will significantly impact the treatment-resistant hypertension market during the forecast period. Moreover, the *anticipated introduction of emerging therapies* with improved efficacy and a further *improvement in the diagnosis rate* are expected to drive the growth of the treatment-resistant hypertension market in the 7MM.

However, several factors may impede the growth of the treatment-resistant hypertension market. The *high incidence of resistant hypertension* in the elderly population complicates the diagnosis and treatment compliance of anti-hypertensives. Additionally, the *elevated occurrence of adverse events* such as cardiovascular events, stroke, and hyperkalemia contributes to high mortality in high-risk RHTN patients. In the mature hypertension market, physician inertia, characterized by a hesitation to prescribe new medications, is likely to impact the *uptake of emerging drugs*. Furthermore, the *limited availability of real-time data* on the epidemiology of the RHTN-specific population adds to the challenges in managing this condition.

Moreover, treatment-resistant hypertension treatment poses a *significant economic burden* and disrupts patients’ overall well-being and QOL. Furthermore, the treatment-resistant hypertension market growth may be offset by *failures and discontinuation of emerging therapies*, *unaffordable pricing*, *market access and reimbursement issues*, and a *shortage of healthcare specialists*. In addition, the *undiagnosed, unreported cases and the unawareness* about the disease may also impact the treatment-resistant hypertension market growth.

*Treatment-Resistant Hypertension Report Metrics* *Details*
Study Period 2019–2032
Treatment-Resistant Hypertension Report Coverage 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan]
Treatment-Resistant Hypertension Market Size in 2021 USD 13.4 Billion
Key Treatment-Resistant Hypertension Companies Idorsia Ltd, Janssen Biotech, Quantum Genomics SA, CinCor Pharma, Ionis Pharmaceuticals, Vifor Pharma, KBP Biosciences, and others
Key Treatment-Resistant Hypertension Therapies Aprocitentan, Firibastat (QGC001), CIN-107, IONIS-AGT-LRx, Veltassa (Patiromer), KBP-5074, and others

*Scope of the **Treatment-Resistant Hypertension** Market Report*

· *Treatment-Resistant Hypertension Therapeutic Assessment: *Treatment-Resistant Hypertension current marketed and emerging therapies
· *Treatment-Resistant Hypertension* *Market Dynamics:* Attribute Analysis of Emerging Treatment-Resistant Hypertension Drugs
· *Competitive Intelligence Analysis:* SWOT analysis and Market entry strategies
· *Unmet Needs, KOL’s views, Analyst’s views, Treatment-Resistant Hypertension Market Access and Reimbursement*

Discover more about treatment-resistant hypertension drugs in development @ *Treatment-Resistant Hypertension Clinical Trials*

*Table of Contents*

1. Treatment-Resistant Hypertension Market Key Insights
2. Treatment-Resistant Hypertension Market Report Introduction
3. Treatment-Resistant Hypertension Market Overview at a Glance
4. Treatment-Resistant Hypertension Market Executive Summary
5. Disease Background and Overview
6. Treatment-Resistant Hypertension Treatment and Management
7. Treatment-Resistant Hypertension Epidemiology and Patient Population
8. Patient Journey
9. Treatment-Resistant Hypertension Marketed Drugs
10. Treatment-Resistant Hypertension Emerging Drugs
11. Seven Major Treatment-Resistant Hypertension Market Analysis
12. Treatment-Resistant Hypertension Market Outlook
13. Potential of Current and Emerging Therapies
14. KOL Views
15. Unmet Needs
16. SWOT Analysis
17. Appendix
18. DelveInsight Capabilities
19. Disclaimer
20. About DelveInsight

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