Pakistan coronavirus cases surge past 25,000, pace quickens: Reuters tally
Friday, 8 May 2020 Coronavirus cases in Pakistan surged past 25,000 on Friday, just hours before the government was due to lift lockdown measures, with the country reporting some of the biggest daily increases in new infections in the world.
India launched a stinging attack on the Pakistan government over its new political map. Ministry of External Affairs SPokesperson Anurag Srivastava said that the claims made by Pakistan are absurd and have no credibility whatsoever. He added that the map proves that Pakistan wants to capture more and more territory by using cross border terrorism. He also lashed out at the Pakistan government's handling of the Kulbhushan Jadhav case saying that Islamabad has not yet reached out to India over the high court decision to inform India to appoint a lawyer for Kulbhushan Jadhav. He added that Pakistan must address basic issues of effective review and adherence to the International Court of Justice verdict on the matter and provide unimpeded, unhindered and unconditional access to Jadhav. Pakistan claims that Jadhav was arrested from Balochistan in 2016 on charges of espionage. India has rejected Pakistan's allegations and said he was kidnapped from the Iranian port of Chabahar. Jadhav had been sentenced to death by a Pakistani military court in early 2017.Watch the full video for all the details.
Credit: HT Digital Content Duration: 02:15Published
Ministry of External Affairs Spokesperson Anurag Srivastava on August 06 cleared India's stand on Pakistan's 'new map' that claims Jammu and Kashmir, Ladakh and parts of western Gujarat. He said, "This type of absurd claims shows that Pakistan wants to take control of more areas by using cross border terrorism."
"Haven't received any communication from Pakistan Government in this regard", said Ministry of External Affairs Spokesperson Anurag Srivastava on August 06 on being asked if Pakistan has reached out to India after Islamabad Court ordered that Indian officials should be given chance to give their stance while hearing petition on appointing lawyer for Kulbhushan Jadhav.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
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