Chimerix Announces Upcoming Presentations at the American Association for Cancer Research Annual Meeting 2021
DURHAM, N.C., April 08, 2021 (GLOBE NEWSWIRE) -- Chimerix (NASDAQ:CMRX), a biopharmaceutical company focused on accelerating the development of medicines to treat cancer and other serious diseases, today announced upcoming poster presentations at the American Association for Cancer Research (AACR) Annual Meeting 2021, which will be held virtually from April 10-15, 2021 and May 17-21, 2021.Details for the poster presentations are as follows:
*ONC201: Characterization and combinatorial efficacy in brain tumors*
*Title:* ADME and toxicology profiles of first-in-class DRD2/ClpP-targeted imipridone ONC201
*Abstract Number:* 1370
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Sara Morrow, M.S., Chimerix
*Session Title:* Pharmacology, Pharmacogenetics, and Pharmacogenomics
*Title:* Response to novel imipridone combination therapies targeting H3K27M mutant diffuse midline glioma (DMG)
*Abstract Number:* 635
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Robyn Borsuk, M.D., Warren Alpert Medical School, Brown University
*Session Title:* Pediatric Cancer: Clinical Investigations
*Title:* The integrated stress response (ISR) is involved in the synergistic combinatorial efficacy of ONC201 and epigenetic modulators in brain tumor cell lines
*Abstract Number: *1156
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Yiqun Zhang, Ph.D., Warren Alpert Medical School, Brown University
*Session Title:* HDAC and Methyltransferase Inhibitors
*ONC201: Combinatorial efficacy in other solid tumors*
*Title:* Combinatorial therapy of imipridones and histone deacetylase inhibitors in Ewing sarcoma cell lines demonstrates synergistic cell death
*Abstract Number: *1060
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Wen-I Chang, M.D., Warren Alpert Medical School, Brown University
*Session Title:* Combination Therapies
*Title:* ONC201 as a novel anti-cancer therapeutic via modulation of inhibitors of apoptosis and up-regulation of DR5 in gastric adenocarcinoma
*Abstract Number: *1044
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Cassandra Parker, M.D., Warren Alpert Medical School, Brown University
*Session Title:* Combination Therapies
*Title:* Imipridones exhibit synergy with sorafenib, HDAC inhibition, PARP inhibition, and proteasome inhibition in liver cancer cell lines
*Abstract Number:* 1040
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Joshua Honeyman, M.D., Warren Alpert Medical School, Brown University
*Session Title:* Combination Therapies
*ONC206: Mechanism of action and biomarkers*
*Title:* Predictive Biomarker Evaluation and Molecular Differentiation for Imipridones ONC201 and ONC206
*Abstract Number:* 393
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Varun V. Prabhu, Ph.D., Chimerix
*Session Title:* Biomarkers Predictive of Therapeutic Benefit
*Title:* Novel imipridone ONC206 suppresses ovarian cancer progression through modulating immune cell response
*Abstract Number:* 1440
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Chi-Lam Au-Yeung, Ph.D., MD Anderson Cancer Center
*Session Title:* Role of Microenvironment in therapeutic response
*ONC212: Efficacy in pancreatic cancer*
*Title:* Combination therapy with MEK inhibitors and a novel anti-neoplastic drug, imipridone ONC212, demonstrates synergy in pancreatic ductal adenocarcinoma cell lines
*Abstract Number: *1006
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Alexander G. Raufi, M.D., Warren Alpert Medical School, Brown University
*Session Title:* Cellular Responses to Anticancer Drugs
*Title:* ONC212-induced impairment of oxidative phosphorylation is synergistic with glycolysis inhibition in treatment of pancreatic cancer in vitro and in vivo
*Abstract Number: *2329
*Date and Time:* April 10, 2021 from 8:30 a.m. - 11:59 p.m. EDT
*Presenter:* Anna Louie, M.D., Warren Alpert Medical School, Brown University
*Session Title:* Metabolic Pathways
Posters will be available for registered attendees on the AACR website on April 10, 2021.
*About Chimerix*
Chimerix is a development-stage biopharmaceutical company dedicated to accelerating the advancement of innovative medicines that make a meaningful impact in the lives of patients living with cancer and other serious diseases. Our three most advanced clinical-stage development programs are BCV, ONC201 and DSTAT. BCV is an antiviral drug candidate developed as a potential medical countermeasure for smallpox and is currently under review for regulatory approval in the United States. ONC201 is currently in a registrational clinical program for recurrent H3 K27M-mutant glioma and a confirmatory response rate assessment is expected later this year. DSTAT is in development as a potential first-line therapy in acute myeloid leukemia and as a potential treatment for acute lung injury in hospitalized COVID-19 patients.
*CONTACT:*
Investor Relations:
Michelle LaSpaluto
919 972-7115
ir@chimerix.com
Will O’Connor
Stern Investor Relations
212-362-1200
will@sternir.com