Tessera Therapeutics to Present New Data Across Preclinical Programs for its Gene Writing™ and Delivery Platforms at the American Society of Gene and Cell Therapy 27th Annual Meeting

SOMERVILLE, Mass., April 22, 2024 (GLOBE NEWSWIRE) -- Tessera Therapeutics, a biotechnology company pioneering a new approach to genome engineering through the development of its Gene Writing™ and delivery platforms, today announced six presentations of new preclinical data at the upcoming American Society of Gene and Cell Therapy (ASGCT) Annual Meeting taking place in Baltimore, Maryland, May 7 – 11, 2024.“We look forward to presenting multiple new datasets at this year’s ASGCT Annual Meeting, including our progress towards in vivo therapies for phenylketonuria, alpha-1 antitrypsin deficiency, sickle cell disease and Wilson’s disease, as well as our advancements in novel T-cell based therapies,” said Michael Severino, M.D., CEO of Tessera Therapeutics. “We continue to focus on the development of transformative genetic medicines through the applications of our Gene Writing and non-viral delivery platforms.”

*Details of the Company’s ASGCT 27*^*th** Annual Meeting presentations are as follows:*

Oral Presentations:

· *Title:* RNA-Based Gene Writer and Lipid Nanoparticle (LNP) Delivery Enables Generation of Functional Chimeric Antigen Receptor (CAR) T Cells with In Vitro and In Vivo Anti-Tumor Activity and T Cell-Specific Genome Engineering In Vivo
*Session:* New Technologies for Gene Targeting and Gene Correction
*Presenter:* Kartika Venugopal, PhD
*Date and Time:* May 7, 2024, 1:45 p.m. – 2:00 p.m. EDT

· *Title:* In Vivo RNA Delivery to T Cells and Hematopoietic Stem Cells in Humanized Mice and Non-Human Primates Using Targeting Lipid Nanoparticles
*Session:* Lipid Nanoparticles
*Presenter:* Rahul Palchaudhuri, PhD
*Date and Time:* May 8, 2024, 4:30 p.m. – 4:45 p.m. EDT

· *Title:* In Vivo HSC Gene Editing for Correction of Sickle Cell Mutation Using RNA Gene Writers
*Session:* Advancements in Technologies for In Vivo Gene Therapies
*Presenter:* Giulia Schiroli, PhD
*Date and Time:* May 10, 2024, 5:00 p.m. – 5:15 p.m. EDT

· *Title:* A Same-Day Manufacturing Platform Leveraging an RNA-Based Lipid Nanoparticle (LNP) Gene Writer System to Generate Chimeric Antigen Receptor (CAR) T Cells
*Session:* Novel Immune Effector Cell Manufacturing
*Presenter:* Kassi Stein, PhD
*Date and Time:* May 11, 2024, 11:45 a.m. – 12:00 p.m. EDT

Poster Presentations:

· *Title:* RNA Gene Writers Drive Therapeutically Relevant Levels of Correction of Monogenic Disease Mutations Expressed in the Liver
*Poster board #:* 597
*Session:* Liver Genetic Diseases
*Presenter:* Anne Bothmer, PhD
*Date and Time:* May 8, 2024, 12:00 p.m. – 7:00 p.m. EDT

· *Title:* Correction of the Human Wilson’s Disease Mutation in an Engineered Disease Mouse Model Using RNA Gene Writers
*Poster board #:* 600
*Session:* Liver Genetic Diseases
*Presenter:* Raed Ibraheim, PhD
*Date and Time:* May 8, 2024, 12:00 p.m. – 7:00 p.m. EDT

*About Tessera Therapeutics*

Tessera Therapeutics is pioneering a new approach to genome engineering through the development of its Gene Writing™ and delivery platforms, with the aim to unlock broad new therapeutic frontiers. Our Gene Writing platform is designed to write therapeutic messages into the genome by efficiently changing single or multiple DNA base pairs, precisely correcting insertions and deletions, or adding exon-length sequences and whole genes. Our proprietary lipid nanoparticle delivery platform is designed to enable the in vivo delivery of RNA to targeted cell types. We believe our Gene Writing and delivery platforms will enable transformative genetic medicines to not only cure diseases that arise from errors in a single gene, but also modify inherited risk factors for common diseases and create engineered cells to treat cancer and potentially autoimmune and other diseases. Tessera Therapeutics was founded in 2018 by Flagship Pioneering, a life sciences innovation enterprise that conceives, creates, resources, and develops first-in-category bioplatform companies to transform human health and sustainability.

For more information about Tessera, please visit www.tesseratherapeutics.com.

*Contact*

Kristin Politi, PhD
LifeSci Communications, LLC
kpoliti@lifescicomms.com
646-876-4783