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Spain allows outdoor dining again in Madrid and Barcelona

Reuters Friday, 22 May 2020
Coronavirus lockdowns will be eased in Spain's capital Madrid and second city Barcelona from Monday to allow outdoor dining and gatherings of up to 10 people as infections have slowed sufficiently there, the government said.
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Barcelona Barcelona City in Catalonia, Spain

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Passengers from Barcelona, Ibiza, Mallorca and Alicante arrive at BirminghamAirport on Monday, after the UK Government imposed coronavirus travelrestrictions for Spain on Saturday and announced 14-day quarantine rules fortravellers.

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Madrid Madrid Capital of Spain

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Firefighters, troops battle forest fire outside Madrid [Video]

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Spanish firefighters and military emergency personnel battled blistering heat on Monday to control a wildfire in the Madrid region that had burned through the night. Edward Baran reports.

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Travellers from Spain to UK react to new quarantine rules [Video]

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Passengers travelling from Madrid to the UK react to the news they will haveto quarantine for 14 days on arrival after Spain reported a spike incoronavirus cases.

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Coronavirus Coronavirus Subfamily of viruses in the family Coronaviridae

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Alcoholism treatment is potentially effective against COVID-19 [Video]

Alcoholism treatment is potentially effective against COVID-19

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.

Credit: ANI    Duration: 01:10Published

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